Two sample MR report
HLA-DRB5_Endothelial Cell (Endo) against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 18 | 0.0343791 | 0.0323829 | 0.3041602 |
| Weighted median | 18 | -0.0241688 | 0.0090162 | 0.0073488 |
| Inverse variance weighted | 18 | -0.0295367 | 0.0066463 | 0.0000088 |
| Simple mode | 18 | -0.0394622 | 0.0149430 | 0.0171636 |
| Weighted mode | 18 | -0.0227681 | 0.0127178 | 0.0912400 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 3.178723 | 16 | 0.9997508 |
| Inverse variance weighted | 7.245735 | 17 | 0.9801378 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0496584 | 0.0246238 | 0.0608331 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0004348 | 0 | TRUE | 0.0481655 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
